What is a septate uterus? Unless you have a medical background, you may struggle for a definition. You may assume that it has something to do with infection because the word is similar to sepsis or septic, but this is not the case. The word comes from septum, which is simply a tissue dividing two chambers, such as those found in the heart or the middle of the nose. A septate uterus is therefore a uterus which is divided into two by a septum.