{"id":106567,"date":"2021-06-30T09:00:42","date_gmt":"2021-06-30T07:00:42","guid":{"rendered":"https:\/\/ivi-fertility.com\/?p=106567"},"modified":"2022-04-12T17:35:14","modified_gmt":"2022-04-12T15:35:14","slug":"duostim-ovarian-stimulation","status":"publish","type":"post","link":"https:\/\/ivi-fertility.com\/blog\/duostim-ovarian-stimulation\/","title":{"rendered":"DuoStim ovarian stimulation : less time to obtain a healthy embryo"},"content":{"rendered":"<p>Once again, IVI wins the race against time, on this occasion using the DuoStim strategy. At the <a href=\"https:\/\/www.eshre.eu\/ESHRE2021\"><strong>37<sup>th<\/sup> annual ESHRE congress<\/strong><\/a> which this year for the second time, due to the health situation, is held on line, Dr Mar\u00eda Cerrillo, a gynaecologist with IVI Madrid, presented the work titled \u201cThe DuoStim strategy shortens the time to obtain an euploid embryo in poor prognosis patients: a non-inferiority randomized controlled trial\u201d.<\/p>\n<p>We work constantly to provide options to patients with severe prognoses, for whom reducing the time to obtain oocytes and embryos is key to having a healthy baby. The DuoStim protocol consists of performing two consecutive stimulations without waiting for menstruation. This technique is an alternative for poor responders who need to accumulate a large number of oocytes, and later embryos, in the shortest time possible, to perform a preimplantation genetic test. IVI is the first to compare DuoStim results with those of two conventional delayed stimulations. The main difference is the reduction of the time necessary to obtain a healthy embryo by nearly half.<\/p>\n<p>&nbsp;<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_68_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title \" >Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ivi-fertility.com\/blog\/duostim-ovarian-stimulation\/#Two_groups_of_patients_with_ovarian_stimulation_for_a_healthy_embryo\" title=\"Two groups of patients with ovarian stimulation for a healthy embryo\">Two groups of patients with ovarian stimulation for a healthy embryo<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ivi-fertility.com\/blog\/duostim-ovarian-stimulation\/#Less_time_to_obtain_healthy_embryos\" title=\"Less time to obtain healthy embryos\">Less time to obtain healthy embryos<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Two_groups_of_patients_with_ovarian_stimulation_for_a_healthy_embryo\"><\/span>Two groups of patients with ovarian stimulation for a healthy embryo<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>For this study IVI recruited 80 patients all over age 38 who, due to their characteristics, required a <a href=\"https:\/\/ivi-fertility.com\/assisted-reproduction-treatments\/pgd-pgt\/\">preimplantation genetic testing<\/a>. Two groups were established, one with DuoStim and another with two delayed stimulations.<\/p>\n<p>\u201cAlthough there have already been studies and data on performing two consecutive stimulations in certain patients, we are the first to conduct a comparison of two stimulations in the same cycle with two delayed stimulations. The DuoStim idea arose after verifying that oocytes obtained in phases other than the follicular phase are equally useful and viable. We concluded that patients stimulated by DuoStim were able to reduce by half the time necessary to obtain a healthy embryo for transfer, therefore making a reduction in the time to achieve pregnancy more likely\u201d, explains Dr Cerrillo.<\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Less_time_to_obtain_healthy_embryos\"><\/span>Less time to obtain healthy embryos<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u201cUpon comparing the results of the two groups, it was determined that there was no variation in the days on which the two stimulations were performed, nor in the number of oocytes or healthy embryos obtained. The main difference was in the number of days that were necessary to obtain a healthy embryo. In the case of the patients stimulated with DuoStim, the time necessary to obtain a euploid embryo was 23.3 days versus 44.1 days in the control group, or group of patients stimulated by means of two conventional delayed stimulations\u201d, Dr Cerrillo says.<\/p>\n<p>Three common questions arise:<\/p>\n<ul style=\"list-style-type: disc\">\n<li>How to mature the oocytes to schedule the puncture?<\/li>\n<li>Is it necessary to leave the smaller oocytes without extracting them when making the first puncture?<\/li>\n<li>How long is it necessary to wait between the first puncture and the second stimulation?<\/li>\n<\/ul>\n<p>In the case of IVI, the response to this last question is to wait five days to start the second stimulation after the puncture.<\/p>\n<p>The characteristics of the patients in both groups were similar (over 38, mean AMH 0.92, similar BMI and antral follicle count). The differences in the cycles between both groups were also similar (gonadotropin dose, days of stimulation, fertilisation rate, blastocyst rate, implantation, pregnancy, etc.). The only difference was the time needed to obtain a (chromosomally normal or healthy) euploid embryo, in which case the time was cut by half.\u00a0 \u00a0\u00a0<\/p>\n<p>\u201cDuoStim is proposed as a fundamental tool for patients who need to have and accumulate the largest number of healthy embryos for purposes of performing preimplantation genetic diagnosis; less than optimal patients, or poor responders, with a certain profile, for whom we would be saving very valuable time, time which they do not always have\u201d, Dr. Cerrillo notes.<\/p>\n<p><strong><em><u>\u00a0<\/u><\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"Once again, IVI wins the race against time, on this occasion using the DuoStim strategy. At the 37th annual ESHRE congress which this year for the second time, due to the health situation, is held on line, Dr Mar\u00eda Cerrillo, a gynaecologist with IVI Madrid, presented the work titled \u201cThe DuoStim strategy shortens the time&#8230; <a class=\"view-article\" href=\"https:\/\/ivi-fertility.com\/blog\/duostim-ovarian-stimulation\/\">View Article<\/a>","protected":false},"author":34,"featured_media":106569,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[156,64],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>DuoStim ovarian stimulation : less time to obtain a healthy embryo<\/title>\n<meta name=\"description\" content=\"IVI compares DuoStim results with two protocols of ovarian stimulation, to reduce the time necessary to obtain a healthy embryo.\" \/>\n<meta name=\"robots\" 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