Once again, IVI wins the race against time, on this occasion using the DuoStim strategy. At the 37th<\/sup> annual ESHRE congress<\/strong><\/a> which this year for the second time, due to the health situation, is held on line, Dr Mar\u00eda Cerrillo, a gynaecologist with IVI Madrid, presented the work titled \u201cThe DuoStim strategy shortens the time to obtain an euploid embryo in poor prognosis patients: a non-inferiority randomized controlled trial\u201d.<\/p>\n
For this study IVI recruited 80 patients all over age 38 who, due to their characteristics, required a preimplantation genetic testing<\/a>. Two groups were established, one with DuoStim and another with two delayed stimulations.<\/p>\n
\u201cUpon comparing the results of the two groups, it was determined that there was no variation in the days on which the two stimulations were performed, nor in the number of oocytes or healthy embryos obtained. The main difference was in the number of days that were necessary to obtain a healthy embryo. In the case of the patients stimulated with DuoStim, the time necessary to obtain a euploid embryo was 23.3 days versus 44.1 days in the control group, or group of patients stimulated by means of two conventional delayed stimulations\u201d, Dr Cerrillo says.<\/p>\n
Three common questions arise:<\/p>\n
In the case of IVI, the response to this last question is to wait five days to start the second stimulation after the puncture.<\/p>\n
The characteristics of the patients in both groups were similar (over 38, mean AMH 0.92, similar BMI and antral follicle count). The differences in the cycles between both groups were also similar (gonadotropin dose, days of stimulation, fertilisation rate, blastocyst rate, implantation, pregnancy, etc.). The only difference was the time needed to obtain a (chromosomally normal or healthy) euploid embryo, in which case the time was cut by half.\u00a0 \u00a0\u00a0<\/p>\n
\u201cDuoStim is proposed as a fundamental tool for patients who need to have and accumulate the largest number of healthy embryos for purposes of performing preimplantation genetic diagnosis; less than optimal patients, or poor responders, with a certain profile, for whom we would be saving very valuable time, time which they do not always have\u201d, Dr. Cerrillo notes.<\/p>\n
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