{"id":107805,"date":"2022-07-05T16:00:28","date_gmt":"2022-07-05T14:00:28","guid":{"rendered":"https:\/\/ivi-fertility.com\/?p=107805"},"modified":"2022-07-01T15:08:45","modified_gmt":"2022-07-01T13:08:45","slug":"implantation-failure","status":"publish","type":"post","link":"https:\/\/ivi-fertility.com\/blog\/implantation-failure\/","title":{"rendered":"Implantation failure and endometrial receptivity: myths and realities"},"content":{"rendered":"<p>The endometrium and the embryo both play a fundamental role in the gestation process. At the <a href=\"https:\/\/www.eshre.eu\/Annual-Meeting\">38th Congress of the European Society of Human Reproduction and Embryology (ESHRE)<\/a>, <a href=\"https:\/\/www.ivi-rmainnovation.com\/investigators\/juan-garcia-velasco\/\">IVIRMA Chief Scientific Officer Juan Antonio Garc\u00eda Velasco<\/a> and IVI Vigo Chief Medical Officer Elkin Mu\u00f1oz examine the role of the endometrium and the embryo in recurrent implantation failure and biochemical pregnancies.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_68_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title \" >Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ivi-fertility.com\/blog\/implantation-failure\/#Implantation_failure_What_is_it_and_what_causes_it\" title=\"Implantation failure: What is it and what causes it?\">Implantation failure: What is it and what causes it?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ivi-fertility.com\/blog\/implantation-failure\/#What_factors_influence_the_success_of_treatments\" title=\"What factors influence the success of treatments?\">What factors influence the success of treatments?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ivi-fertility.com\/blog\/implantation-failure\/#Biochemical_pregnancy_and_its_possible_relationship_to_the_embryo_or_endometrium\" title=\"Biochemical pregnancy and its possible relationship to the embryo or endometrium\">Biochemical pregnancy and its possible relationship to the embryo or endometrium<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ivi-fertility.com\/blog\/implantation-failure\/#Relationship_between_biochemical_pregnancies_and_the_embryo_or_the_endometrium\" title=\"Relationship between biochemical pregnancies and the embryo or the endometrium\">Relationship between biochemical pregnancies and the embryo or the endometrium<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Implantation_failure_What_is_it_and_what_causes_it\"><\/span><strong>Implantation failure: What is it and what causes it? <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>Implantation failure<\/strong> occurs when pregnancy is not achieved after the transfer of two chromosomally normal embryos or four blastocysts. When this happens, we immediately wonder: What is the cause? Is the problem attributable to the embryo or the endometrium? This question has given rise to different hypotheses and numerous investigations regarding the role of both in implantation.\u00a0<\/p>\n<p>At this year\u2019s ESHRE, Dr. Garc\u00eda Velasco led an invited session hosted by the Merck Group for a discussion titled \u201cMyths and Realities of Endometrial Receptivity in Assisted Reproduction.\u201d During this discussion, he highlighted the areas of priority and main factors for achieving success in reproductive treatments.<\/p>\n<p>Dr. Garc\u00eda Velasco says that <a href=\"https:\/\/ivi-fertility.com\/assisted-reproduction-treatments\/highly-complex-reproduction-implantation-failure-and-recurrent-miscarriage\/\">recurrent implantation failure<\/a> is \u201ca concept that has recently been redefined, we know that in most cases it is the embryo that fails. In this sense, it becomes essential to know what embryos are like &#8216;inside&#8217;, to go beyond morphology, beyond what we see under the microscope; to study them in depth. And for this, pre-implantation genetic testing (PGT-A) will help us to confirm whether the embryos are chromosomally normal or not, which is the reason for, not all, but the vast majority of implantation failures&#8221;.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_factors_influence_the_success_of_treatments\"><\/span><strong>What factors influence the success of treatments?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Assisted reproduction centres are currently studying parameters that have a greater or lesser influence on the success of treatments. Some of these studies may become especially relevant for improving results for this type of patient, while others may not be so relevant.<\/p>\n<p><strong>Endometrial thickness<\/strong> is a simple parameter, but it is clearly related to reproductive success. If endometrial thickness is less than 6-7 millimetres, the treatments are less successful. But are endometrial transcriptomic studies still as revolutionary as they first seemed?<\/p>\n<p>Dr. Garc\u00eda Velasco draws the following conclusion: &#8220;The many receptivity tests on the market are very interesting tools, but they do not benefit all patients equally. We have a long way to go to understand which patients have the best results with these techniques. The same is true for new fields of study such as endometrial and vaginal microbiota and chronic endometritis; two attractive and promising areas with wide-ranging perspectives. However, we still have to clarify the diagnostic criteria and, in particular, the profile of patients who will benefit from them, as well as confirming that the treatments for the abnormalities found really improve the patients\u2019 prognosis&#8221;.<\/p>\n<p>Science is advancing and opening new horizons every day, which means that professionals in the assisted reproduction field are moving towards more precise diagnoses and more personalised treatments. The objective of all this is the same as always: to fulfil the gestational desire of patients in the shortest possible time and with the best guarantees. Choosing, understanding and applying the most suitable techniques for each case brings us one step closer to achieving this objective.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Biochemical_pregnancy_and_its_possible_relationship_to_the_embryo_or_endometrium\"><\/span><strong>Biochemical pregnancy and its possible relationship to the embryo or endometrium <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>As we noted earlier, the embryo and endometrium both play a fundamental role in the gestation process. The causes of biochemical pregnancies are still unknown, but there are various factors related to this. These may include age, poor quality eggs and embryos, or altered endometrial receptivity.<\/p>\n<p>The medical director of IVI Vigo and A Coru\u00f1a, Elkin Mu\u00f1oz, states the following: &#8220;Biochemical pregnancy is a very common situation in natural reproduction, but even more so in assisted reproduction. It occurs when, after an egg is fertilised and the embryo is implanted in the mother&#8217;s uterus, the embryonic development process is interrupted after a few days and the pregnancy stops progressing. It occurs more frequently in the field of assisted reproduction since we monitor the increase in pregnancy hormone levels in the patients&#8217; blood at an early stage, meaning we detect more biochemical pregnancies than in natural gestation\u201d.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Relationship_between_biochemical_pregnancies_and_the_embryo_or_the_endometrium\"><\/span><strong>Relationship between biochemical pregnancies and the embryo or the endometrium<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The purpose of the study led by Dr. Mu\u00f1oz and submitted at this year\u2019s ESHRE, \u201cIs Biochemical Pregnancy Loss (BPL) Associated with Embryo or Endometrium? A Multicentre Retrospective Study with 7,000+ Cases,\u201d is precisely to examine this possible relationship.<\/p>\n<p>&#8220;This is a retrospective study with a sample of more than 7,000 patient cases over 8 years, resulting in an overall biochemical pregnancy rate of 8%. After analysing embryos for chromosomal content or analysing endometrial receptivity, we have seen that this frequency is not reduced. Therefore, it is necessary to learn more about the intrinsic phenomenon that leads to biochemical pregnancy in order to advance in its prevention,&#8221; adds Dr. Mu\u00f1oz.<\/p>\n<p>The 7,000 cases studied are divided into various groups:<\/p>\n<ol>\n<li>Patients whose embryos were studied with the aim of selecting chromosomally normal ones.<\/li>\n<li>Patients who have undergone an endometrial receptivity study.<\/li>\n<li>Patients who have received both a chromosomal and an endometrial analysis.<\/li>\n<li>Patients who belong to the control group and who have only undergone conventional IVF.<\/li>\n<\/ol>\n<p>Dr. Mu\u00f1oz concludes the following: &#8220;Although the <strong>biochemical pregnancy<\/strong> rate is slightly lower in the group with a higher level of testing (PGT-A and ERA), in actual fact, as we mentioned before, the differences are not statistically significant. This leads us to conclude that we must continue to investigate the causes of a still unresolved problem, affecting almost 1 in 10 pregnant women&#8221;.<\/p>\n","protected":false},"excerpt":{"rendered":"The endometrium and the embryo both play a fundamental role in the gestation process. At the 38th Congress of the European Society of Human Reproduction and Embryology (ESHRE), IVIRMA Chief Scientific Officer Juan Antonio Garc\u00eda Velasco and IVI Vigo Chief Medical Officer Elkin Mu\u00f1oz examine the role of the endometrium and the embryo in recurrent&#8230; <a class=\"view-article\" href=\"https:\/\/ivi-fertility.com\/blog\/implantation-failure\/\">View Article<\/a>","protected":false},"author":34,"featured_media":107806,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[170,218],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Implantation failure and endometrial receptivity: myths and realities<\/title>\n<meta name=\"description\" content=\"Implantation failure occurs when pregnancy is not achieved after the transfer of two chromosomally normal embryos or four blastocysts.\" 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