{"id":108322,"date":"2023-03-30T17:15:21","date_gmt":"2023-03-30T15:15:21","guid":{"rendered":"https:\/\/ivi-fertility.com\/?p=108322"},"modified":"2023-03-30T17:15:21","modified_gmt":"2023-03-30T15:15:21","slug":"uterine-fibroids-premature-ovarian-failure","status":"publish","type":"post","link":"https:\/\/ivi-fertility.com\/blog\/uterine-fibroids-premature-ovarian-failure\/","title":{"rendered":"Uterine fibroids and premature ovarian failure: three IVI studies have received awards at the SRI"},"content":{"rendered":"<p>For yet another year, IVI has been present at the congress of the <a href=\"https:\/\/www.sri-online.org\/\">Society for Reproductive Research (SRI)<\/a>, which held its 70th edition in Brisbane. It is one of the most important reproductive medicine events in the world, which is why we presented several papers, some of which received awards.<\/p>\n<p>Research activity is one of our mainstays. For this reason we lead several projects with the aim of helping all women and couples who want to have a child. Today we talk about the main studies that IVI presented at SRI 2023.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_68_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title \" >Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ivi-fertility.com\/blog\/uterine-fibroids-premature-ovarian-failure\/#Therapies_for_women_with_premature_ovarian_failure\" title=\"Therapies for women with premature ovarian failure\">Therapies for women with premature ovarian failure<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ivi-fertility.com\/blog\/uterine-fibroids-premature-ovarian-failure\/#Treatment_of_uterine_fibroids\" title=\"Treatment of uterine fibroids\">Treatment of uterine fibroids<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ivi-fertility.com\/blog\/uterine-fibroids-premature-ovarian-failure\/#A_way_to_improve_oocyte_quality\" title=\"A way to improve oocyte quality\">A way to improve oocyte quality<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ivi-fertility.com\/blog\/uterine-fibroids-premature-ovarian-failure\/#Trace_elements_an_influential_factor_in_reproductive_outcomes\" title=\"Trace elements, an influential factor in reproductive outcomes\">Trace elements, an influential factor in reproductive outcomes<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ivi-fertility.com\/blog\/uterine-fibroids-premature-ovarian-failure\/#Research_one_of_IVIs_mainstays\" title=\"Research, one of IVI\u2019s mainstays\">Research, one of IVI\u2019s mainstays<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Therapies_for_women_with_premature_ovarian_failure\"><\/span>Therapies for women with premature ovarian failure<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>One of the lines of research IVI is working on is <strong>therapies for women suffering from Premature Ovarian Failure<\/strong>. Also known as <strong>premature ovarian insufficiency (POI)<\/strong>, this pathology refers to menstrual and ovulatory abnormalities in women under the age of 40. It should not be confused with early menopause, which is the end of a woman&#8217;s reproductive capacity.<\/p>\n<p>However, POI also causes fertility problems and makes it difficult to become pregnant. In many cases it prevents the women who suffer from it from being able to conceive with their own eggs. The IVI Foundation\u2019s Endometrial Stem Cell Biology and Uterine Bioengineering group, led by Dr. Irene Cervell\u00f3, presented the study &#8216;Bioengineering an Ovarian-Specific ECM Hydrogel to Treat Premature Ovarian Failure&#8217;, awarded the President&#8217;s Presenter&#8217;s Award, the highest recognition granted by the scientific society.<\/p>\n<p>\u201cThis study could become a therapeutic option for women with POI as the results of the study are very promising. It shows that hydrogel combined with growth factors improved the number of mature eggs obtained in mice, compared to animals that did not receive the treatment, or received alternative treatments,\u201d explained Dr. Cervell\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Treatment_of_uterine_fibroids\"><\/span>Treatment of uterine fibroids<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Uterine fibroids are <strong>the most common female tumors<\/strong> and are always benign. In fact, 70% of women of childbearing age may have fibroids. Most are asymptomatic. However, 1 in 4 cases may involve menorrhagia (very heavy or prolonged periods), discomfort during sexual intercourse, pelvic or abdominal pain.<\/p>\n<p>Furthermore, uterine fibroids increase the risk of miscarriages. They make it difficult to conceive naturally, meaning they have a <strong>negative effect on female fertility<\/strong>. This is why IVI focuses part of its research on the treatment of benign tumors.<\/p>\n<p>At the SRI, Dr. Hortensia Ferrero, a researcher at the IVI Foundation, won the President&#8217;s Presenter&#8217;s Award for her study &#8216;Doxercalciferol Decreases Uterine Fibroid Growth Rate Through the Regulation of ECM Synthesis and Cell Proliferation&#8217;.<\/p>\n<p>\u201cThe results of our study highlight the potential of vitamin D analogues, specifically Doxercalciferol, as a therapeutic option for the <a href=\"https:\/\/ivi-fertility.com\/blog\/fibroid-removal-necessary\/\"><strong>treatment of uterine fibroids<\/strong><\/a> in patients who wish to maintain their fertility. Doxercalciferol reduces the growth of fibroids by 42%. This is possible through the expression of genes involved in cell proliferation and extracellular matrix production, These are the two main pathways for the progression of this type of tumor,\u201d said Dr. Ferrero.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"A_way_to_improve_oocyte_quality\"><\/span>A way to improve oocyte quality<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Another of the main causes of infertility today is <strong>low oocyte quality. <\/strong>This problem that not only affects natural pregnancies but also the outcomes of fertility treatments. The increasing age at which women become mothers has a direct influence on this factor. The effect of cancer treatments such as chemotherapy on women is also a cause.<\/p>\n<p>In both cases, increased levels of oxidation in the oocyte could be one of the mechanisms involved. This is the result of another study led by the IVI Foundation, with encouraging results for women who want to become mothers.<\/p>\n<p>\u201cIn our study &#8216;Nicotinamide Mononucleotide supplementation improves oocyte quality in chemotherapy induced ovarian damage mouse models&#8217; we evaluated whether oral supplementation with nicotinamide mononucleotide (NMN) can reverse the decrease in oocyte quality associated with chemotherapy-induced damage in an animal model. This is the first time that the role of NMN has been investigated against the damage caused by cancer treatments,\u201d said Dr. Sonia Herraiz, researcher at the IVI Foundation and supervisor of the study.<\/p>\n<p>NMN is a precursor of the active substance Nicotinamide Adenine Dinucleotide (NAD+). This is a key molecule in multiple biological processes, with antioxidant potential.<\/p>\n<p>\u201cFollowing IVF in animals, we observed higher fertilization rates and improved embryo development. Therefore, we can indicate that treatment with NMN is a promising therapeutic strategy for improving oocyte quality, for which there is currently no viable treatment,\u201d added Dr. Herraiz.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Trace_elements_an_influential_factor_in_reproductive_outcomes\"><\/span>Trace elements, an influential factor in reproductive outcomes<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The <strong>general decline in fertility in recent decades<\/strong> is also attributed to environmental and lifestyle factors, such as diet. In this regard, the following is another of the studies presented by IVI and supervised by Dr. Francisco Dom\u00ednguez: \u201cPositive association between essential trace elements in female biological matrices and IVF outcomes in euploid single embryo transfer cycles.\u201d It identifies the trace elements associated with better and worse reproductive outcomes in in-vitro fertilization treatments.<\/p>\n<p>\u201cOur data showed that a higher concentration of trace elements, such as copper and the copper\/zinc ratio in follicular fluid and plasma, and manganese in plasma, was significantly associated with higher ovarian response to hormonal stimulation and better embryological outcomes in IVF treatment. In contrast, higher lithium concentrations in follicular fluid were associated with lower ovarian reserve, lower response to ovarian stimulation and lower fertilization rate in IVF treatment. These results suggest a direct impact between trace element levels and IVF treatment outcomes,\u201d concluded Dr. Francisco Dom\u00ednguez, researcher at the IVI Foundation and supervisor of the study.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Research_one_of_IVIs_mainstays\"><\/span>Research, one of IVI\u2019s mainstays<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Another of the studies presented by IVI that got an award by the SRI focuses on analyzing <strong>embryos\u2019 developmental behavior<\/strong>, beyond the day of transfer, in cultures prolonged in the laboratory until approximately day 12, depending on whether they are euploid (chromosomally normal), trisomy 21 (with an extra chromosome 21 or Down&#8217;s Syndrome) or monosomy 21 (with one less chromosome 21). This study will enable us to discover when developmental differences are detected in the embryos\u2019 morphology and in the expression of their chromosomes.<\/p>\n<p>\u201cThis will help us to see if it is possible to silence the extra chromosome in some embryos using CRISPR technology in human cell lines, in order to attempt to do the same in the human embryo in a second phase,\u201d stated Dr. Inma S\u00e1nchez, gynecologist at IVI Barcelona and supervisor of the study.<\/p>\n<p>IVI currently has <strong>7 research centers in 9 countries<\/strong>, clearly reflecting its commitment to advance in treatments that help patients to become parents.<\/p>\n<p>This is reflected by Dr. Juan Antonio Garc\u00eda Velasco, IVI&#8217;s Scientific Director. \u201cResearch has been guiding our progress for more than 3 decades. It is this effort to constantly advance in the knowledge of the field we work in and the discovery of the best options for our patients that has enabled us to become a benchmark in the assisted reproduction sector and to achieve the best results in our treatments. Today we continue to study, learn and make progress, so that tomorrow any fertility problem can be solved with the help of science. Forums such as the SRI provide a space for the exchange of knowledge to outline the current focal points that will mark the future of our profession\u201d.<\/p>\n<p>The findings obtained by IVI have a clinical application in the treatments we offer our patients, such as uterine fibroids. That is why we are experts in highly complex cases, and we have the most <strong>advanced technology<\/strong> for our treatments. If you would like more information on this subject,<a href=\"https:\/\/ivi-fertility.com\/ask-for-an-appointment\/\"> you can contact us by telephone or by filling in our online form so that our team can call you.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"For yet another year, IVI has been present at the congress of the Society for Reproductive Research (SRI), which held its 70th edition in Brisbane. It is one of the most important reproductive medicine events in the world, which is why we presented several papers, some of which received awards. Research activity is one of&#8230; <a class=\"view-article\" href=\"https:\/\/ivi-fertility.com\/blog\/uterine-fibroids-premature-ovarian-failure\/\">View Article<\/a>","protected":false},"author":34,"featured_media":108325,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[218,64,167,304],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Uterine fibroids and premature ovarian failure, IVI studies awarded<\/title>\n<meta name=\"description\" content=\"Uterine fibroids are the most common female tumors and are always benign. 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