{"id":109865,"date":"2024-03-15T17:30:37","date_gmt":"2024-03-15T15:30:37","guid":{"rendered":"https:\/\/ivi-fertility.com\/?p=109865"},"modified":"2024-03-14T17:46:30","modified_gmt":"2024-03-14T15:46:30","slug":"recurrent-miscarriages","status":"publish","type":"post","link":"https:\/\/ivi-fertility.com\/blog\/recurrent-miscarriages\/","title":{"rendered":"Metformin improves reproductive outcomes in patients with insulin resistance"},"content":{"rendered":"<p>Every year, the scientific community in reproductive medicine gathers at the Annual Meeting of the <a href=\"https:\/\/www.sri-online.org\/\">Society for Reproductive Investigation (SRI).<\/a> This year&#8217;s edition took place in the city of Vancouver, Canada. <strong>Researchers from around the world shared the latest advances in research<\/strong> focused on enhancing reproductive environments and providing hope to women and couples in need of reproductive medicine to fulfill their desire to start a family.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_68_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title \" >Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ivi-fertility.com\/blog\/recurrent-miscarriages\/#What_is_the_influence_of_insulin_resistance_in_recurrent_miscarriages\" title=\"What is the influence of insulin resistance in recurrent miscarriages?\">What is the influence of insulin resistance in recurrent miscarriages?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ivi-fertility.com\/blog\/recurrent-miscarriages\/#Study_of_telomeres_and_their_length_to_reverse_ovarian_aging\" title=\"Study of telomeres and their length to reverse ovarian aging\">Study of telomeres and their length to reverse ovarian aging<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ivi-fertility.com\/blog\/recurrent-miscarriages\/#IVI_presence_at_the_SRI_Congress\" title=\"IVI presence at the SRI Congress\">IVI presence at the SRI Congress<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_is_the_influence_of_insulin_resistance_in_recurrent_miscarriages\"><\/span><strong>What is the influence of insulin resistance in recurrent miscarriages?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Among the most prominent studies by IVI researchers is &#8220;Metformin treatment decreases clinical miscarriage and improves live birth rates in infertile patients with insulin resistance.&#8221; <strong>This work demonstrates how metformin treatment reduces clinical miscarriage rates and improves live birth rates in women undergoing assisted reproduction processes with insulin resistance<\/strong>. It is worth noting that <strong>metformin is an oral antidiabetic drug<\/strong> of the biguanide type. It helps control blood glucose levels, decrease glucose absorption from food, and reduce glucose production in the liver.<\/p>\n<p>&#8220;<em>Imbalance in insulin resistance during embryo implantation and pregnancy leads to elevated levels of maternal and fetal blood glucose. This results in complications that may lead to miscarriage. <strong>The use of metformin has been described as a treatment that leads to a decrease in blood glucose levels<\/strong> without associated risks. In addition it improves endometrial function, positioning it as a possible treatment for women where insulin resistance is a significant factor potentially related to poorer reproductive outcomes. In this regard, we evaluated the effect of metformin on the reproductive outcomes of these women<\/em>,&#8221; explains Dr. Hortensia Ferrero, researcher at the IVI Foundation and author of this study.<\/p>\n<p><strong>Recurrent miscarriages affect approximately 2-5% of reproductive-aged patients<\/strong>. Various pathologies have been described as possible causes of pregnancy loss:<\/p>\n<ul>\n<li>Chromosomal and uterine abnormalities<\/li>\n<li>Endocrine imbalances<\/li>\n<li>Autoimmune factors<\/li>\n<li>Obstetric complications<\/li>\n<li>Metabolic abnormalities<\/li>\n<\/ul>\n<p>In this context, <strong>previous studies have shown that insulin resistance can significantly impact female reproductive dysfunction<\/strong>.<\/p>\n<p>&#8220;<em>We have observed an increase in rates of spontaneous <a href=\"https:\/\/ivi-fertility.com\/blog\/chemical-pregnancy\/\">clinical miscarriage<\/a> in women with insulin resistance. This is likely due to impaired cellular glucose uptake due to insulin resistance, leading to inadequate embryonic nutrition and energy deficiency culminating in pregnancy loss. This increased clinical miscarriage rate in women with insulin resistance was significantly reduced in those treated with metformin compared to those who did not receive treatment. Additionally, <strong>we have observed an increase in the rate of live births in these patients with insulin resistance and metformin treatment compared to those who did not take it<\/strong>, even compared among patients without insulin resistance<\/em>,&#8221; adds Dr. Ferrero.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Study_of_telomeres_and_their_length_to_reverse_ovarian_aging\"><\/span><strong>Study of telomeres and their length to reverse ovarian aging<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>While<strong> aging cannot be avoided, research focuses on how to prevent it, even reverse it<\/strong>. This is the focus of the study titled &#8220;Telomere protection is impaired in the ovary of SAMP8 mouse model with reproductive senescence,&#8221;. This work points to telomere shortening as a sign of ovarian aging.<\/p>\n<p>&#8220;<em>Telomeres are a great marker for assessing aging. In this sense, we have seen that there is a family of proteins &#8211; shelterins &#8211; that protect and &#8216;care for&#8217; these telomeres. Specifically, TRF1 is one of the most relevant. Thus, we have studied whether these protective proteins are altered in the ovaries of a prematurely aging mouse model (SAMP8), confirming indeed that prematurely aging mice have less TRF1 in their ovaries, and specifically, in their follicles. This may cause telomeres to shorten prematurely and, consequently, age prematurely<\/em>,&#8221; explains Dr. Juan Antonio Garcia Velasco, scientific director of IVI, co-director of IVI Madrid, and author of this study.<\/p>\n<p>It should be noted that telomeres are special DNA sequences at the ends of chromosomes, with repetitive sequences recognized as their ends, preventing the chromosome from breaking or being damaged. <strong>The potential alteration mentioned by Dr. Garc\u00eda Velasco may result in inadequate telomere protection. <\/strong>That&#8217;s why understanding the mechanisms that produce it can help determine which treatments can prevent or even reverse reproductive aging.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"IVI_presence_at_the_SRI_Congress\"><\/span><strong>IVI presence at the SRI Congress<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In total, <strong>IVI has presented nearly twenty research presentations in this edition<\/strong>, addressing topics of great scientific interest. Among them are endocrine disruptors and their effect on fertility, polycystic ovaries, or stem cells, in addition to those mentioned above. <strong>At IVI, the cornerstone of success lies in its powerful research capabilities, always with the aim of providing you with the most advanced techniques and treatments.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"Every year, the scientific community in reproductive medicine gathers at the Annual Meeting of the Society for Reproductive Investigation (SRI). This year&#8217;s edition took place in the city of Vancouver, Canada. Researchers from around the world shared the latest advances in research focused on enhancing reproductive environments and providing hope to women and couples in&#8230; <a class=\"view-article\" href=\"https:\/\/ivi-fertility.com\/blog\/recurrent-miscarriages\/\">View Article<\/a>","protected":false},"author":34,"featured_media":109867,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[257,219,218,64],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Recurrent miscarriages due to insuline resistance, a research by IVI<\/title>\n<meta name=\"description\" content=\"Recurrent miscarriages affect approximately 2-5% of reproductive-aged patients. 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