This technique removes apoptotic spermatozoa – those which will die without achieving fertilisation – and selects the healthy ones, thus increasing the possibility of pregnancy.


This technique can be used with any kind of patient, but is mainly used with:

  • Patients who are to be treated with artificial insemination.
  • Infertile patients who have a high level of DNA fragmentation in their spermatozoa.
  • Patients who have had repeated miscarriages with an unidentified cause.
  • Patients who have had at least one previous treatment cycle or who have poor embryo quality which is not attributable to the oocytes.

This technique has been in use for more than 25 years, and it is routinely used in the field of clinical immunology and haematology.


90% of patients who undergo an assisted reproduction treatment at IVI become pregnant.


IVI is a pioneer in the latest assisted reproduction technology in order to present the best results.


97% of our patients recommend IVI.
IVI provides personalised care and support during all stages of treatment.


We are not the most expensive choice. We offer the most treatment options in order to achieve the best results.


Why choose IVI?

Our IVI assisted reproduction clinics are pioneers in the application of immunomagnetic cell sorting (MACS), which allows healthy spermatozoa to be separated from damaged ones, improving the pregnancy rate by around 10 – 15% in some cases.


The MACS technique consists of the use of tiny biodegradable magnetic particles that have an antibody attached (the protein annexin V) which is able to detect the spermatozoa that will die before fertilising the ovum. The antibody fastens on to these, enabling them to be separated from the healthy spermatozoa.

Once the spheres with the annexin V attached have been added to the semen sample, this is passed through columns while being exposed to a weak magnetic field. The apoptotic spermatozoa will be retained on the column walls, while the healthy spermatozoa that have shown no evidence of cell death are drawn through the column by gravity. In this way, we can obtain healthy spermatozoa with the best physiological qualities for use in assisted reproduction treatments.


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