2 January 2018

Ovarian rejuvenation: strides forward in fertility treatment

By the Editorial Comitee IVI Blog

These days there are more options to address infertility than ever before, and medical conditions which would have once dashed any hope of falling pregnant are now being successfully treated. Ovarian rejuvenation is a relatively new concept in the field, but one that is helping fertility specialists to make great strides forward. Using newly developed techniques, women who have suffered early menopause or other conditions which limit fertility may still conceive using their own eggs. These may include women under the age of 38 who are either postmenopausal or perimenopausal for less than 5 years, or younger women who have a low reserve of eggs. The process stimulates the ovaries, allowing for the creation and release of new eggs. In this case, any child conceived would carry genetic material from the mother. This may be the preferable option for some women, rather than using donor eggs. The procedure of ovarian rejuvenation is relatively painless and may be worth an attempt before moving on to other treatments.


Limited eggs

It is more common in the 21st century to begin trying to conceive later in life, so it makes sense that there are plenty of women (and men) who do not discover issues surrounding their fertility until there is a time constraint. A woman’s peak fertility is in her 20s, and from the age of 35 onwards fertility decreases fairly rapidly. This means that when problems with fertility are discovered, they need to be addressed quickly. IVF is a great first option for many patients, and a treatment that IVI has had much success with. If the patient is able to use her own eggs then the procedure is relatively straightforward, beginning with stimulation of the ovaries to release multiple eggs at once, progressing to fertilisation of these eggs with sperm from the male partner or from a donor, and completing with the transfer of an embryo to the uterus. However, some women may find that they do not have enough eggs in reserve, or there may be some other issue with the eggs that they do have. While IVI is conducting research into ovarian rejuvenation, this is not yet offered to patients. For women with limited eggs or eggs of a poor quality, using a donor is still the optimal choice.

Egg production happens during gestation of the female foetus, and by the time baby girls are born they already have all of the eggs they will ever release over their lifetime stored within their ovaries. The average number of eggs that women are born with is around one to two million, but this varies. By the time puberty hits roughly 300,000 eggs remain. An average of one egg is released each month, but there is of course the possibility that more will be released. If fertilised together, these will result in multiple births. As a woman ages, she naturally has fewer and fewer eggs, and therefore fewer chances to conceive. As time goes on there is also a reduced chance that a fertilised egg will implant successfully into the lining of the womb. Ovarian rejuvenation is the process by which the production of eggs is artificially stimulated, giving women the chance to produce more eggs than they would naturally have been able to, and therefore giving them the chance to conceive using their own genetic material.



Process of ovarian rejuvenation

One way in which ovarian rejuvenation can be achieved is through Ovarian Fragmentation for Follicular Activation (OFFA). This allows the aging process to be reversed slightly and activates dormant follicles which go on to become viable eggs. At IVI’s clinic in Valencia, which is one of 11 English-speaking fertility clinics in Spain, the OFFA technique is currently being researched and used in a very small number of cases to give women another option before resorting to egg donation. The procedure is generally pain-free, and patients can go home on the same day. A simple blood test is carried out first to make sure that the patient is a suitable candidate for this procedure. This is to reduce the chance of subjecting a patient to medical intervention which in their particular case may have a reduced likelihood of resulting in pregnancy. As at May 2017, IVI had achieved four pregnancies in patients with ovarian failure, a rate which we hope to continue to improve as the procedure develops.

A second ovarian rejuvenation technique involves infusing stem cells into the ovarian artery. This is still being developed by our experts, and we hope to reap the rewards of our research in the near future.


Hope for the future

While ovarian rejuvenation is still in the early stages of development, IVI has already carried it out successfully. An important aspect of our work is our continued focus on research and development of new and existing technologies that facilitate conception. Infertility is more treatable today than it has ever been in human history. However, just because we are able to offer IVF and other techniques such as fertility preservation and artificial insemination does not mean that we are resting on our laurels. With continued improvements and innovation in the field of fertility, we hope to be able to provide a realistic option for any and all patients under the age of 50 who are subject to infertility causes. Apart from ovarian rejuvenation we are also funding research into oocyte vitrification, a process which rapidly slows the aging process in eggs. This means that women may put off trying for a baby for longer, without the fear of decreased fertility and poorer quality eggs. This is also a great option for women who need to undergo treatments for cancer, and who now have the chance to preserve their fertility.

With these new strides forward in treatments for infertility, IVI is leading the field in innovative new procedures, researching potential ways to preserve or stimulate fertility. This means that IVI’s patients have a greater chance of seeing their dream of starting a family come true.

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  • Rosa says:

    Wow this a very amazing growth of science. I’m 35 years old and I have early menopause, I would like to be part of this study, i would like to be a volunteer for this study. Because i want to have a child from my own egg. If you don’t mind please contact me in my email rosa.l.******@gmail.com
    Thank you

  • Blog.UK says:

    Dear Rosa,
    We know ovarian rejuvenation attires a lot of interest, but unfortunately it’s still something that’s being researched so we cannot offer it to our patients.

  • andreia ribeiro says:

    I am very interested in the ovarian rejuvenation. Is it possible to get it done?
    Thank you.

  • Blog.UK says:

    Dear Andreia, thank you for your interest. Unfortunately, ovarian rejuvenation is still performed in the frame of our research projects, so we cannot offer it yet to any patient.

  • Victoria says:

    I am 33yrs old and I have Premature Ovarian Failure. I am very interested in being part of a study in the US to find a treatment. I have done so much of my own research to find the root cause and possible treatments for POF, as all doctors I have seen only give alternate options. Please contact me with any information.

  • Blog.UK says:

    Dear Victoria,
    Unfortunately ovarian rejuvenation is still being researched, so we cannot offer it as a treatment for our patients.

  • DOHA says:

    my age 44 years old and I have FSH 20.LH 6.and irregular menses.I wont to do ovarian rejuvenation.could you help you

  • Blog.UK says:

    Dear Doha,
    We aren’t currently offering ovarian rejuvenation as a treatment. However, we are doing our best in researching this since we know many women could benefit from it.
    Thank you for your comment.

  • Dana Mettlewsky says:

    How much are these treatments?
    How does a person qualify to get treated?
    Please advise.
    Thank you

  • Rosanne Bruno says:

    Are doctors using this procedure in New York area? Can it be successful for POF patients ?

  • Blog.UK says:

    Dear Dana,
    We are not yet offering it as a treatment to any patient, since it is still being researched. We will do our best to continue with this so much needed research!

  • Blog.UK says:

    Dear Rosanne,
    Ovarian Rejuvenation is one of our main research lines nowadays at IVI. However, we are not offering it as a treatment to any patient. We will do our best to continue with this so much needed research!

  • Prabashnee says:

    I Ave had prp done in November last year and my periods were normal although they varied between 28 an 38 day cycles, I now had my last period on June 28 and I am wondering has the benefit of this surgery stopped or is there a time frame for how long it assists

  • Blog.UK says:

    Please contact us or fill the following form so our specialists can evaluate your history. All the best.

  • Esther says:

    Esther am 49 years old and am looking for a child ,I feel this ovarian rejuvenation will help me maybe by the time you finish your research.

  • Blog.UK says:

    Be very much hope so, too 🙂
    Our goal is to help all our patients to have a baby.

  • Khyati says:


    I am 32 now and i dont get my periods yet due to primary ovarian failure.. My secondary sex organs like uterus is also small and breast development is also not satisfactory. Currently my AMH level is <0.010..my FSH level is very high and I did my HRT before 15 years but due to side effects i've stopped taking it.. Now i am unmarried and want to develope my family.. Is there any medicine to produce your own eggs besides the option of eggs donor.. ?

    I have heard about ovary transplant and oogonial stem cells ! Can anyone please help me to guide ?

    I am totally depressed ?

    Can rejuvenation help me ?

  • KD says:


    Can this article help to build a hope for primary ovarian failure ? I am 32 and i dont get my periods yet . I have high FSH and my AMH is <0.010

    Can i go through this treatment to conceive ?

  • Su says:

    Hi, I have read from website’s of couple of hospitals, one in India and other in Bangkok, who have already been doing stem cell treatment for infertility. Please explain. I am keen to try.

  • Blog.UK says:

    Dear Khyati,
    We can only advise you to speak to one of our specialists, who will be able to evaluate your case and recommend you the best options for you to get pregnant.

  • Blog.UK says:

    Dear Khyati, unfortunately we are not offering ovarian rejuvenation as a treatment currently, since it is still being researched.

  • Blog.UK says:

    For the moment ovarian rejuvenation is not something we are offering to our patients, since it is still being researched. We very much hope to be able to offer it as soon as possible.

  • padma says:

    Hi I am 37 years, and on Menopause for 3 years, is it possible to conceive with own egg

  • Mouna says:

    Dear sir
    I am Libyan women seeking for children my age 46 year old ( birth day 24-9-1971), and my husband 48 year old ( birth on 1969) we attempted eight times IVF once in Tunisia and other in Turkey, India, Egypt and Libya but Unfortunately not succeed, last month they told me there is no Ovulation . recently I heard there is new technic to Ovarian Rejuvenation by plasma treatment , could you please help me to get child by Plasma activation my ovarian, and I am ready to pay all the costs. I will be very grateful for your help for treatment. my phone numbers 0021891162**** – 0021892626****. could tell if possible start treatment, if possible I will come and start treatment

  • Peter B says:

    Rosa, you should look up PRP (plasma rich in platelets) for ovarian rejuvenation. This a very new approach as far as treating ovaries but is being used to restore hair, skin tone, joints etc. With the latter cases the technology has been around for a while.
    I was reading up on it a year ago and left off the subject in favor of donor eggs– mostly due to the lack of facilities here in Chile.
    The are clinics practicing this method in Greece, New York, India and elsewhere.
    As I said, it is new and maybe subject to an element of propaganda so do your reading.

  • admin says:

    Dear Mouna, we aren’t currently offering ovarian rejuvenation to our patients, since it is still a technique that is being researched. If you want to discuss with one of our doctors a suitable fertility treatment for you, fill the following form so we can contact you asap.

  • admin says:

    Dear Padma,
    It is our doctors who will be able to answer that question once they’ve taken a look at your medical history and examined you during your first consultation. We strongly advice you fill the following form so we can inform you about the next step to ask for an appointment.

  • Tanisha king says:

    This process started with a research study partnership between Stanford University and a Japanese lab. They have currently moved from research to actually offer it as a treatment option at the Japanese clinic. I cannot recall the clinic’s name. I believe the process is called in-vitro activation. Look it up.

  • Veni says:

    My follicles are not responding event after taking Goanalif -f 300IU for 8 days along with Menotas HP 75 .
    No suggested for stem cell therapy as i have 5 follicles.
    Could you help us regarding this treatment and cost.

  • IVI says:

    Dear Veni, we recommend you call us at 08 000 850 035 so we’ll be able to answer your medical questions.

  • Vesna says:

    I’ve gone through many IVF trials without success and now, I’m 49.
    However, I’m not interested in donor eggs.
    The technologies that you are developing look really promising to me.
    I would be interested in stem cell treatment as well as in vitro activation.
    Although I understand that this technology is still in developing, please let me know if you provide some research/clinical trial as I would be interested to take part in it.
    Thank you.

  • IVI says:

    Dear Vesna,
    Ovarian rejuvenation is not yet a treatment we can offer to our patients, it is still being researched. I’m afraid we are not looking for any candidates for the ongoing studies. If you finally decide to go for an assisted reproduction treatment, please take into account that the limit age for women is 50 in Spain. Thank you for your interest.

  • Naz says:

    I am interested in ovarian rejuvenation with stem cell. Which one of you clinics does this procedure. I live in Southern California, but I would not mind to travel to get this procedure.

  • IVI says:

    Dear Naz, unfortunately we are not offering ovarian rejuvenation as a treatment yet, since this technique is still at a research phase. Remember we also have clinics in the US.

  • Lara says:

    Hi, I am also interested in ovarian rejuvenation and in my research I found a team in Serbia performing it. Segova team is apparently performing it commercially. How does this compare to your ovarian rejuvenation? I’m 39 and have POF.

  • Leena Patel says:

    Do you have any idea when PRP ovarian rejenvation will be able?

  • IVI says:

    Dear Lara, this technique is still being researched, although the results until now are quite promising we are not able to offer it yet to our patients.

  • IVI says:

    Dear Leena, it is not possible for us to predict when this technique will be offered to our patients as one of our treatments, since it is still being researched. We do our best because we know many women could benefit from it however!

  • Tracy Leske says:

    I have been researching PRP and I wanted to know whereabouts does the injection go? For sports injuries it is done localised to the injury (eg.knee, hip, etc), but where do they inject the platelets?

    Thank you

  • Infertility clinic says:

    Very good information is given.
    Thank you.

  • Infertility clinic says:

    Hi, thank you for the valuable information.

  • Monsa says:

    I am also interested in this procedure. Can you help. I am 51

  • IVI says:

    Dear Monsa, this technique is still being researched. In any case, every patient needs a personnalised evaluation done by a specialist. Thank you for your interest!

  • Anna says:

    Ive done PRP in Ukraine (2019) and at my doctors in Germany (2020). It works.

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